Dr. R. Ranjith Kumar

Dr. R. Ranjith Kumar

Name: Dr. R. Ranjith Kumar
Designation: Associate Professor
Phone: 9787722916
Email: ranjithkumar@cutn.ac.in

 

Biographic Sketch:
Raju Ranjith Kumar (RRK) was born in The Nilgiris, India, in 1977. He received M.Sc. degree in chemistry from the Government Arts College, Ooty, in 2001 and Ph.D. degree in chemistry from Madurai Kamaraj University (MKU) in 2008.During 2008-09, he worked as a post-doctoral fellow under Prof. Henri B. Kagan at the University of Paris, France. RRK was awarded the Young Scientist Fellowship by the Department of Science and Technology, New Delhi, during 2009–10. On 18 March 2010, he joined as an Assistant Professor in the Department of Organic Chemistry, MKU. He was a visiting scientist at the Universidad Complutense, Madrid, Spain, in 2011. In July 2017, RRK was honored by MKU with a citation award, appreciating his remarkable research contributions. He is a life member of the Chemical Research Society of India and the National Magnetic Resonance Society of India. RRK moved to the Central University of Tamil Nadu as an Associate Professor in the Department of Chemistry on 1 Dec 2022. His present research interest is rooted in synthetic organic chemistry, in particular, the synthesis of small-molecule fluorescent heterocyclic probes for sensor applications and structural elucidation using NMR spectroscopy.
   
Research Highlights :

Our research group has been focusing on synthesizing libraries of novel hybrid molecules starting from active methylene compounds like 1,3-cyclohexanedione, N-alkyl-4-piperidone, thiophen-3-ones, cyclooctanone, cyclododecanone, thiazolidine-2,4-dione, aroyl acetonitriles, malononitrile and steroids such as estrone, trans-androsterone and dehydroandrosterone. These hybrid molecules comprise a maximum of up to seven hetero atoms (N, O or S) in the ring systems. The syntheses of these hybrid molecules have been achieved employing environmentally benign protocols like multi-component domino reactions and atom economic 1,3-dipolar cycloadditions. The heterocycles were found to be efficient sensors of metal ions and organic nitro compounds apart from exhibiting interesting biological activities.



Recent Publications :

List of Publications: 

  1. One-Pot Three-Component Domino Synthesis of Isoxazolo[5,4-b]pyrano[2,3-f]quinolines: An Efficient Fluorescent Turn-off Chemosensor for Picric Acid, S. Raja Rubina, S. Indhu Leka, K. Sathya Priya, R. Ranjith Kumar*, S. Murugesan,* ChemistrySelect 2022, 7, e202203902, IF: 2.109 (clickhere)
  2. Synthesis of Epiminocyclohepta[b]pyrazolo[4,3-e]pyridines from Tropinone: Fluorescent “Turn On–Off” Chemosensors for the Sequential Detection of Al3+, Cd2+ and Pb2+ in Nanomolar Concentration, S. Raja Rubina, P. Stalin, C. S. Meenatchi, S. Murugesan*, R. Ranjith Kumar*, J. Mol. Struct., 2022, 1269, 133724, IF: 3.196 (Clickhere) 
  3. Phenothiazine Tethered Biaryls as Fluorescent Probes for Multi-analyte Detection, S. S. Roja, S. Raja Rubina, A. Shylaja, R. Ranjith Kumar*, ChemistrySelect 2022, 7, e202200217, IF: 2.109 (Clickhere) 
  4. Pyrano[2,3-f]pyrazolo[3,4-b]quinoline-3-carbonitriles: A three-component Synthesis and AChE Inhibitory Studies, R. V. Sumesh, R. Ranjith Kumar,* A. I. Almonsour, R. Suresh Kumar, M. K. M. Ashraf, Synth. Commun. 2021, 51, 1058–1065, IF: 2.007 (Clickhere)
  5. Imidazolium Ylide Mediated Tandem Knoevenagel–Michael–O-Cyclization Sequence for the Synthesis of Multi-substituted 4,5-Dihydrofurans, S. Sivakumar, A. I. Almonsour, R. Suresh Kumar, N. Arumugam, R. Ranjith Kumar* Synth. Commun. 2021, 51, 234–244, IF: 2.007 (Clickhere)  
  6. Structural, Hirshfeld, Spectroscopic, Quantum Chemical and Molecular Docking Studies of N′-(4-(4-Chlorophenyl)-1,3-dicyano-5,6,7,8,9,10-hexahydrobenzo[8]annulen-2-yl)N,N-dimethyl-formimidamide as CCR2 inhibitors, S. Pangajavalli, R. Ranjith Kumar, S. Ramaswamy, J. Mol. Struct., 2021, 1239, 130503, IF: 3.196 (Clickhere) 
  7. Coordinated Compliance of Chloro-Methyl and Bromo-Methyl Exchange Rule in two Dihydrofuran Carbonitrile Derivatives, V. Rajni Swamy, R.V. Krishnakumar, N. Srinivasan, S. Sivakumar, R. Ranjith Kumar, J. Mol. Struct. 2021, 1228, 129741, IF: 3.196 (Clickhere)
  8. Ionic liquid Mediated Synthesis and in vitro Mechanistic Exploration of Polycyclic Cage‐like Heterocyclic Hybrid, R. Suresh Kumar, A. I. Almonsour, N. Arumugam, D. Kotresha, J. C. Menendez, R. Ranjith Kumar, J. Heterocycl. Chem. 2021, 58, 580–588, IF: 2.193 (Clickhere)  
  9. Thiazole-Tethered Biaryls as Fluorescent Chemosensors for the Selective Detection of Fe3+ Ions, B. Mariammal, A. Shylaja, S. Vivek Kumar, S. Raja Rubina, R. Ranjith Kumar* J. Heterocycl. Chem. 2020, 57, 3882–3889, IF: 2.193  (Clickhere)  
  10. Phenothiazine Tethered 2-Aminopyridine-3-carbonitrile: Fluorescent Turn-off Chemosensor for Fe3+ Ions and Picric Acid, S. S. Roja, A. Shylaja, R. Ranjith Kumar* ChemistrySelect 2020, 5, 2279–2283, IF: 2.109 (Clickhere)  
  11. Novel Blue Emissive Dimethylfuran Tethered 2-Aminopyridine-3-carbonitrile: Dual Responsive Fluorescent Chemosensor for Fe3+ and Picric Acid in Nanomolar Detection Limit, A. Shylaja, S. Raja Rubina, S. S. Roja, R. Ranjith Kumar* Dyes Pigments 2020, 174, 108062, IF: 4.889 (Clickhere) 
  12. Access to Highly Substituted Oxazoles by the Reaction of α-Azidochalcone with Potassium Thiocyanate, M. Harisha, P. Dhanalakshmi, R. Suresh, R. Ranjith Kumar, S. Muthusubramanian, Beilstein J. Org. Chem. 2020, 16, 2109–2118, IF: 2.883 (Clickhere)  
  13. Azafluorene Derivatives as Inhibitors of SARS CoV-2 RdRp: Synthesis, Physicochemical, Quantum Chemical, Modeling and Molecular Docking Analysis, M. Venkateshan, M. Muthu, J. Suresh, R. Ranjith Kumar, J. Mol. Struct., 2020, 1220, 128741, IF: 3.196 (Clickhere) 
  14. In vitro Mechanistic Exploration of Novel Spiropyrrolidine Heterocyclic Hybrids as Anticancer Agents, R. Suresh Kumar, A. I. Almonsour, N. Arumugam, F. Mohammad, R. Ranjith Kumar, Front. Chem. 2020, 8, Article 465, doi: 10.3389/fchem.2020.00465, IF: 5.221 (Clickhere)  
  15. Structural, Hirshfeld, Spectroscopic, Quantum Chemical and Molecular Docking Studies on 6b′,7′,8′,9′-Tetrahydro-2H,6′H-spiro[acenaphthylene-1,11′-chromeno[3,4-a]pyrrolizine]-2,6′(6a′H,11a′H)dione, S. Pangajavalli, R. Ranjith Kumar, S. Ramaswamy, J. Mol. Struct. 2020, 1209, 127921, IF: 3.196 (Clickhere) 
  16. Substitution Induced Switch Between Pictet-Spengler and Eschweiler-Clarke Reactions: Selective Synthesis of Spiro Acenaphthylene Pyrrolo[1,2-b]isoquinoline/Pyrrolidine Hybrids, R. Suresh Kumar, A. I. Almansour, N. Arumugam, R. Ranjith Kumar, Tetrahedron Lett. 2020, 61, 151606, IF: 2.415 https://doi.org/10.1016/j.tetlet.2020.151606  
  17. TMSOTf‐Catalysed Synthesis of 2,4,5‐Trisubstituted Imidazoles from Vinyl Azides and Nitriles, M. B. Harisha, P. Dhanalakshmi, R. Suresh, R. Ranjith Kumar, S. Muthusubramanian, N. Bhuvanesh, ChemistrySelect 2019, 4, 2954-2958, IF: 2.109 https://doi.org/10.1002/slct.201801543  
  18. Discovery of Novel Cage-like Heterocyclic Hybrids as Anti-inflammatory Agents Through the Inhibition of Nitrite, PGE2 and TNF-α, R. Suresh Kumar, P. Antonisamy, A. I. Almansour, N. Arumugam, D. M. Al-Thamili, R. Ranjith Kumar, H-R. Kim, K-B. Kwon, Bioorg. Chem. 2019, 91, 103180, IF: 5.275 https://doi.org/10.1016/j.bioorg.2019.103180  
  19. Four-Component Domino Synthesis of Pyrazolo[3,4-h]quinoline-3-carbonitriles: “Turn-Off” Fluorescent Chemosensor for Fe3+ Ions, A. Shylaja, S.S. Roja, R. Vishnu Priya, R. Ranjith Kumar,* J. Org. Chem. 2018, 83, 14084-14090, IF: 4.354 https://doi.org/10.1021/acs.joc.8b01991  
  20. A One-pot Access to Pyridine/Benzo Fused Cyclododecanes via Multi-component Tandem Reactions, S. Vivek Kumar, M. Anusha Rani, A. I. Almansour, R. Suresh Kumar, S. Athimoolam, R. Ranjith Kumar,* Tetrahedron, 2018, 74, 4569-4577, IF: 2.457 https://doi.org/10.1016/j.tet.2018.07.020  
  21. Synthesis of Spiro-linked Quinolinone-Pyrrolidine/Pyrrolo[1,2-c]thiazole-Oxindole/ Acenaphthalene Hybrids via Multi-component [3+2] Cycloaddition, R.V. Sumesh, A. Shylaja, R. Ranjith Kumar,* A.I. Almansour, R. Suresh Kumar, Tetrahedron Lett. 2018, 59, 4086-4089, IF: 2.415 https://doi.org/10.1016/j.tetlet.2018.10.002  
  22. Synthesis of Indole–Cycloalkyl[b]pyridine Hybrids via a Four-component Six-step Tandem Process, M. Muthu, R. Vishnu Priya, A. I. Almansour, R. Suresh Kumar, R. Ranjith Kumar* Beilstein J. Org. Chem. 2018, 14, 2907-2915, IF: 2.883 https://doi.org/10.3762/bjoc.14.269  
  23. Dipolar Cycloaddition Based Multi-component Reaction: Synthesis of Spiro Tethered Acenaphthylene–Indolizine–Pyridinone Hybrids, R. Suresh Kumar, A.I. Almansour, N Arumugam, G. Periyasami, S. Athimoolam, R. Ranjith Kumar, M. Asad, M. Asiri, Tetrahedron Lett. 2018, 59, 3336-334, IF: 2.415 https://doi.org/10.1016/j.tetlet.2018.07.051  
  24. Stereoselective Green Synthesis and Molecular Structures of Highly Functionalized Spirooxindole-Pyrrolidine Hybrids: A Combined Experimental and Theoretical Investigation, R. Suresh Kumar, A. I. Almansour N. Arumugam S. M. Soliman, R. Ranjith Kumar M. Altaf, H. A. Ghabbour B. S. Krishnamoorthy, J. Mol. Struct, 2018, 1152, 266–275, IF: 3.196 https://doi.org/10.1016/j.molstruc.2017.09.073  

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