Coordination Chemistry, Bioinorganic and Inorganic Medicinal Chemistry
Our group is working on the design and characterization of, conjugated polymers towards sensors, hyper branched polymers as smart drug delivery vehicles, Coloured Latexes.
Our research focuses the field of Bioinorganic and Medicinal Inorganic Chemistry - specially in investigating the role of metal complexes in medicine.The group aims to understand the role of metals in nature and are interested in the application oriented development of metal-containing compounds as new metallonucleases, metalloproteases, nucleic acids probe and anticancer agents
The main research themes are:-
Development of metal-based anticancer agents
We have designed and synthesized certain copper(II) and ruthenium(II) mixed-ligand metal complexes and tested their cytotoxicity with the various origin of cancer cell lines. Besides synthetic inorganic chemistry, structural characterization of new metal complexes and their cytotoxicity, we strongly aim on the investigate their mechanisms of action of their anticancer activity. We discovered a few complexes have shown promising cytotoxicity inthe cancer cell
Copper(II) complexes as metallonucleases and metalloproteases
We have designed and synthesized different types of mixed ligand copper(II) complexes having both DNA and protein binding and cleaving properties. We have shown that the cleavage of DNA and protein occurs via metal-assisted self-activated mechanistic pathway. In addition to that, the redox active copper(II) complexes exhibited DNA cleavage by producing ROS in the presence of activating agent such as ascorbic acid.
Fluorescent probes for nucleic acids
The main aim of this project is to develop a fluorescent probe for nucleic acids such as dsDNA, G-quadruplexes, and i-motif DNAs. Certain Ru(II) polypyridyl complexes which act as a better fluorescent probe for dsDNA, are discovered to be better staining agents for nonviable cells than for viable cells.Currently, we work on designing certain probes for targeting/stabilizing G-quadruplex and i-motif DNAs.
Porphyrin-based PDT agents
One of our recent focus lies on designing and synthesizing certain porphyrin compounds which are conjugated with cancer cell targeting group for photodynamic therapeutic (PDT) applications. In this project, we are mainly aiming to improve the cellular internalization and photosensitizing property of photosensitizer selectively at cancer sites.
Development of Nanocarriers for targeted drug delivery at the cancer site
In this project, we have designed and developed a mesoporous silica (MSN) nanocarriers for targeted delivery of cytotoxic copper(II) complexes at the cancer site. Loaded nanocarriers were treated with normal and cancer cell lines. Interestingly, the developed MSN nanocarriersfunctionalized with folic acid selectively delivered the cytotoxic copper(II) complex at cancer cells and sparing the normal healthy cells.
Metalloporphyrin nanoparticles: Coordinating diverse theranostic functions
Shuai Shao, VenugopalRajendiran, Jonathan F. Lovell
Coordination ChemistryReviews2017, In press.
Synthesis, structures, and DNA and protein binding of ruthenium(II)-p-cymenecomplexes of substituted pyridylimidazo[1,5-a]pyridine: enhanced cytotoxicity ofcomplexes of ligands appended with a carbazole moiety
ThemmilaKhamrang, RadhakrishnanKartikeyan, MarappanVelusamy, Venugopal Rajendiran, RajakumarDhivya, BalajiPerumalsamy, Mohammad AbdulkadherAkbarshad and MallayanPalaniandavar
RSC Adv., 2016, 6, 114143.
New [Ru(5,6-dmp/3,4,7,8-tmp)2(diimine)]2+ complexes: Non-covalent DNA and protein binding, anticancer activity and fluorescent probes for Nuclear and protein components
VenugopalRajendiran, MallayanPalaniandavar, VaiyapuriSubbarayanPeriasamy,
J. Inorg. Biochem. 2012, 116, 151.
Cleavage of Proteins by a Mixed-Ligand Copper(II) Phenolate Complex: Hydrophobicity of the DiimineColigand Promotes
Venugopal Rajendiran,Mallayan Palaniandavar, Palanisami Swaminathan and Lakhsmanan Uma,
Inorg. Chem. 2007, 46, 10446.
Mixed Ligand Copper(II)-phenolate Complexes: Effect of Co-ligand on Enhanced DNA and Protein Binding, DNA Cleavage and Anticancer Activity
Venugopal Rajendiran, RamasamyKarthik, MallayanPalaniandavar*, HelenStoeckli-Evans, Mohamad AbdulkaderAkbarsha, VaiyapuriSubbarayanPeriyasamy, Bangalore Suresh Srinag and HanumanthappaKrishnamurthy
Inorg.Chem. 2007, 46, 8208.
From left to right Mrs M.Kiruthika, Dr.V.Rajendiran, Ms S.Karpagam, Mr. M.Anjaneyulu, Mr.R.Kartikeyan