Category: Department of Chemistry

Dr. Rajkumar Subramani

Dr. Rajkumar Subramani

Dr. Rajkumar Subramani

Name: Dr. Rajkumar Subramani
Designation: Assistant Professor
Phone: 9342228386


Biographic Sketch:
Dr. S. Rajkumar is currently working as an Assistant Professor in the Department of Chemistry at the Central University of Tamil Nadu, Thiruvarur, India. He completed his BSc in Chemistry with a gold medal from Government Arts College, Nandanam, Chennai, and his MSc in Chemistry from Ramakrishna Mission Vivekananda College, Chennai. He then pursued his PhD at VIT University, Vellore, India, where he was awarded a CSIR-SRF under the guidance of Prof. Thirumanavelan Gandhi. His research project focused on "Ru(II)-catalyzed--carboline and phthalazinones/pyridazinones directed C-H, C-H/N-H, C-H/O-H activation and functionalization-Isolation of cycloruthenated complexes and its application towards anticancer study." During his postdoctoral studies, he further honed his skills at ShanghaiTech University, China, delving into asymmetric enamide functionalization and kinetic resolution reactions utilizing BINOL and SPINOL-based phosphoric acid catalyst reactions. Subsequently, his pursuit of excellence led him to secure the Korean Research Fellowship (Brain Pool Fellow) and National Research Fellow funded grants, where he served as a principal investigator at Kyungpook National University, South Korea in the field of radiopharmaceutical development for cancer diagnosis. Later, he contributed as a Research Fellow at Massachusetts General Hospital, Harvard Medical School, USA, where he deepened his understanding the radiosynthesis of nanoparticles, antibody-drug conjugates, and small molecules tailored for targeted drug delivery in cancer imaging and radiotherapy applications.

Research Highlights :

We are medicinal chemist our research group mainly focusing on themetal catalyst C-H activation and asymmetric catalytic reaction for the drug development in cancer diagnosis and therapy.

  • Esterase enzyme responsive tumor targeted drug delivery.
  • Site selective antibody drug conjugation.
  • Boron Neutron Capture therapy. 

Recent Publications :

  1. Subramani Rajkumar, Mengyao Tang and Xiaoyu Yang. Chiral Phosphoric Acid Catalyzed Kinetic Resolution of 2‐Amido Benzyl Alcohols: Asymmetric Synthesis of 4H‐3,1‐Benzoxazines.Angew. Chem. Int.Ed.2020, 59,2333–2337.DOI: 10.1002/anie.201913896.
  2. Subramani Rajkumar, Shunlong He and Xiaoyu Yang. Kinetic Resolution of Tertiary 2- Alkoxycarboxamido-Allylic Alcohols by Chiral Phosphoric Acid Catalyzed Intramolecular Transesterification. Angew.Chem. Int.Ed.2019,58, 10315 –10319. DOI: 10.1002/anie.201905034.
  3. Subramani Rajkumar, Jiawen Wang, Sujuan Zheng, Donglei Wang, Xueqian Ye, Xuejiao Li, Qian Peng and Xiaoyu Yang. Regioselective and Enantioselective Synthesis of β‐indolyl Cyclopentenamides Through Chiral Anion Catalysis. Angew.Chem. Int.Ed.2018, 57, 13489 –13494. DOI: 10.1002/anie.201807010.
  4. Subramani Rajkumar, S.A. Savarimuthu, R. Senthilkumaran, C. M. Nagaraja, and T. Gandhi. Expedient Synthesis of New Cinnoline Diones by Ru-Catalyzed Regioselective Unexpected Deoxygenation-Oxidative Annulation of Propargyl Alcohols with Phthalazinones and Pyridazinones.  Chem. Commun.,2016, 52, 2509-2512DOI: 10.1039/C5CC09347C.
  5. Subramani Rajkumar, S. Karthik and T. Gandhi. Ru(II)-Catalyzed b-Carboline Directed C-H Arylation and Isolation of Its Cycloruthenated Intermediates.  J. Org. Chem., 2015, 80, 5532–5545. DOI: 10.1021/acs.joc.5b00411.


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