Dr. D. Siva Sundara Kumar

Dr. D. Siva Sundara Kumar

Name: Dr. D. Siva Sundara Kumar
Designation: Associate Professor
Phone: 04366-277230
Email: d.sivasundarakumar@cutn.ac.in

 

Biographic Sketch:
I am presently serving as an Associate Professor at the Department of Microbiology, Central University of Tamil Nadu, India. Prior to this role, I held a position as a Research Assistant Professor at Hong Kong Baptist University (HKBU) in Hong Kong. During my tenure at HKBU, my responsibilities encompassed both teaching and research endeavours, with a primary focus on microbiology and neurodegenerative diseases. I earned my doctoral degree in fungal biotechnology from the University of Hong Kong (HKU) in 2004. During my time as a PhD fellow at HKU, I had the privilege of gaining valuable insights into fungal taxonomy and diversity under the guidance of the distinguished mycologist, Professor Kevin D. Hyde. Furthermore, I hold Master of Science and Master of Technology degrees, which I acquired from the University of Madras and the Indian Institute of Technology in 1998 and 1999, respectively. During my initial postdoctoral training at the Vaccine R&D Centre at the National Health Research Institutes in Taiwan (2005-2006), I actively contributed to a project titled "Identification of an alternative receptor for the SARS CoV virus." Subsequently, I sought to further enhance my expertise in neuroprotective strategies for addressing neurodegenerative diseases, prompting my decision to assume a postdoctoral fellow position at the School of Chinese Medicine at HKBU from 2006 to 2012. Throughout this tenure, my focus as a postdoctoral fellow was dedicated to unravelling the molecular intricacies of Alzheimer’s and Parkinson's diseases while validating potential therapeutic targets for Alzheimer’s disease treatment. In addition to my research pursuits, I have significantly contributed to laboratory management and provided guidance to PhD students, postdoctoral fellows, and senior research assistants across various research topics. In recognition of my achievements, I was honoured with an outstanding research award in fungal biotechnology from the Venus International Foundation in India in 2022. My research contributions are also underscored by the publication of 49 papers in peer-reviewed journals, reflecting an H-index of 28. Additionally, I have secured two patents in the United States and two in China, along with receiving nine extramural grants from institutions in Hong Kong and India.
   
Research Highlights :

Dr. D. Siva Sundara Kumar’s area of research focuses on the following themes

  1. Discovery and development of antivirals, anti-Alzheimer’s and anti-neurodegenerative agents.
  2. Fungal biotechnology with an emphasis on bioassay-guided fractionation of metabolites
  3. Role of autophagy in mycological and neurodegenerative diseases 
  4. Understanding the role of Kinesin I Heavy Chain (KIF5B), a molecular motor, in Tau phosphorylation, aggregation and neurodegeneration in Alzheimer’s disease and other tauopathies


Recent Publications :

1.      Durairajan SSK*, Singh AK, Saravanan UB, Namachivayam M, Radhakrishnan M, Huang J-D, Dhodapkar R, Zhang H. Gastrointestinal Manifestations of SARS-CoV-2: Transmission, Pathogenesis, Immunomodulation, Microflora Dysbiosis, and Clinical Implications. Viruses. 2023; 15(6):1231. (I.F: 5.818)

2.      Selvarasu K, Singh AK, Iyaswamy A, GopalkrishnashettySreenivasmurthy S, Krishnamoorthi S, Bera AK, Huang JD, Durairajan SSK*. Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models. Front MolBiosci. 2022 Oct 25;9:1050768. https://pubmed.ncbi.nlm.nih.gov/36387285/  (I.F: 6.113),

3.      Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Reddi RN, Kammala AK, Vasudevan K, Senapati S, Zhu Z, Su CF, Liu J, Guan XJ, Chua KK, Cheung KH, Chen H, Zhang HJ, Zhang Y, Song JX,  Durairajan SSK*, Li M*. Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy. Front MolBiosci. 2022 9:1030534

4.      Iyaswamy A, Wang X, Krishnamoorthi S, Kaliamoorthy V, Sreenivasmurthy SG, Durairajan SSK, Song JX, Tong BC, Zhu Z, Su CF, Liu J, Cheung KH, Lu JH, Tan JQ, Li HW, Wong MS, Li M. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models. Redox Biol. 2022 May;51:102280. (IF: 10.787)

5.      Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BC, Cheung KH, Tan JQ, Lu JH, Durairajan SSK*, Song JX*, Li M*. Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. Phytomedicine. 2022  96, 153887.  https://pubmed.ncbi.nlm.nih.gov/34936968/ (IF: 6.656)

6.      Durairajan SSK*, Selvarasu K, Bera MR, Rajaram K, Iyaswamy A, Li M. Alzheimer's Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration. CurrMolPharmacol. 2022;15(2):361-379. (I.F: 3.855)

7.      Liang LJ, Jeewon R, Dhandevi P, Durairajan SSK, Li H, Lin FC, Wang HK. A Novel Species of PenicilliumWith Inhibitory Effects Against Pyriculariaoryzae and Fungal Pathogens Inducing Citrus Diseases. Front Cell Infect Microbiol. 2021 Feb 10;10:604504.

8.      Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammala AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY, Durairajan SSK*, Li M*. Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease. Front Pharmacol. 2020; 11: 584770. (IF 2020: 4.2236).

9.      Iyaswamy A, Krishnamoorthi SK, Zhang H, Sreenivasmurthy SG, Zhu Z, Liu J, Su CF, Guan XJ, Wang ZY, Cheung KH, Song JX, Durairajan SSK*, Li M*. Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease. Phytomedicine. 2021 Oct;91:153648. (IF 2020:5.12)

Iyaswamy A, Krishnamoorthi SK, Song JX, Yang CB, Zhang H, Kaliyamoorthy V, Sravan GS, Wang ZY, Zhu Z, Malampati S, Tong CT, Cheung KH, Lu JH, Durairajan SSK* Li M*. NeuroDefend, a novel traditional Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease. J Food Drug Anal. 2020; 28:132-146. (IF 2019: 4.727).

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