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Research Highlights :
My primary research interest is on Hemostasis and Thrombosis especially in the areas of platelets and coagulation defects. Currently, our research lab is focused on understanding the signaling mechanisms in platelets at various conditions and diseased states. Since matured platelets undergo signal-dependent translational regulation, we study the existence of alternative cell death pathway in platelets that could potentially regulate the platelet function and survival. We have also developed a genetic panel specific for programmed cell death, programmed cell necrosis, and cellular (Platelets) activation. Apart from the above, our lab is intensely focused on the other relevant areas including hematological malignancies in Down-Syndrome, Thrombophilia, Hemophilia, Viral-associated thrombosis and other thrombotic defects.
Recent Publications :
1. Subi TM, Krishnakumar V, Kataru CR, Panigrahi I, Kannan M (2022). Association of VEGF and p53 Polymorphisms and Spiral Artery Remodeling in Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis. Thrombosis and Haemostasis. 122: 363-376.
2. Ahmad F, Kannan M, Ansari AW (2022). Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism. Cytokine and Growth Factor Reviews. 63:58-68.
3. Selvavinayagam ST, Yong YK, Joseph N, Hemashree K, Tan HY, Zhang Y, Rajeshkumar M, Kumaresan A, Kalpana R, Kalaivani V, Monika AVD, Suvaithenamudhan S, Kannan M, Murugesan A, Narayanasamy K, Palani S, Larsson M, Shankar EM and Raju S (2022). Low SARS-CoV-2 viral load among vaccinated individuals infected with Delta B.1.617.2 and Omicron BA.1.1.529 but not with Omicron BA.1.1 and BA.2 variants. Frontiers in Public Health. 10:1018399.
4. Gupta A, Jayakumar MN, Saleh MA, Kannan M, Halwani R, Qaisar R,
Ahmad F (2022). SARS-CoV-2-infection induced growth factors play differential roles in COVID-19 pathogenesis. Life Sciences. 304: 120703
5. Gresele P, Falcinelli E, Bury L, Pecci A, Alessi MC, Borhany M, Heller PG, Santoro C, Cid AR, Orsini S, Fontana P, Candia ED, Podda G, Kannan M, Jurk K, Castaman G, Falaise C, Guglielmini G, Noris P, BAT-VAL study investigators (2021). The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders. Journal of Thrombosis and Haemostasis. 19(5):1364-1371
6. Kannan M, Ahmad F, Saxena R (2019). Platelet activation markers in evaluation of thrombotic risk factors in various clinical settings. Blood Reviews. 37:100583
7. Ahmad F*, Kannan M*, Obser T, Budde U, Schneppenheim S, Saxena R, Schneppenheim R (2019). Characterization of VWF gene conversions causing von Willebrand disease. British J of Haematology. (5):817-25.
8. Maharana S, Roy CR, Kishor K, Ranjan R, Ahmad F, Mahapatra M, Saxena R, Kannan M (2023). Depolarized Mitochondrial Membrane Potential and Elevated Calcium in Platelets of Sickle Cell Disease. Indian Journal of Hematology and Blood Transfusion. https://doi.org/10.1007/s12288-023-01640-7
9. Gupta A, Al-Tamimi AO, Halwani R, Alsaidi H, Kannan M, Ahmad F (2022). Lipocalin-2, S100A8/A9 and Cystatin C: potential predictive biomarkers of cardiovascular complications in COVID-19. Experimental Biology and Medicine. Jul;247(14):1205-1213
10. Gerotziafas GT, Catalano M, Theodorou Y, Dreden PV, Marechal V, Spyropoulos AC, Carter C, Jabeen N, Harenberg J, Elalamy I, Falanga A, Fareed J, Agathaggelou P, Antic D, Antignani PL, Bosch MM, Brenner B, Chekhonin V, Colgan MP, Dimopoulos MA, Douketis J, Elnazar EA, Farkas K, Fazeli B, Fowkes G, Gu Y, Gligorov J, Ligocki MA, Indran T, Kannan M, Kantarcioglu B, et al (2021). The COVID-19 Pandemic and the Need for an Integrated and Equitable Approach: An International Expert Consensus Paper. Thrombosis and Haemostasis. Aug;121(8):992-1007
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