Name: Dr. Ravanan P Designation: Associate Professor & Head Phone: 04366-277230 Email:ravanan@cutn.ac.in
Biographic Sketch:
Currently, I am working as Associate Professor and Head of the Department of Microbiology. I have more than 13 years of Teaching/Research/Administrative experience from various reputed institutes. Since 2010, I worked in the Vellore Institute of Technology (VIT) as a faculty until I joined the Central University of Tamil Nadu, Thiruvarur. Prior to this, I have worked in the Indian Institute of Science, Bangalore and Sanford Burnham Prebys Medical Discovery Institute, USA for my Pre-doctoral (2 years) and postdoctoral (2 years) research experience respectively. Additionally, I have served as the Head, Department of Biosciences in VIT from 2016 - 2018. Under my supervision, 4 Ph.D. students have graduated. After joining CUTN, I have received three research grants from SERB and two fellowships (ERASMUS and CEFIPRA).
The research of our lab aims at studying how chronic inflammation, endoplasmic reticulum stress, and oxidative stress can affect brain function at the molecular level. These stresses are associated phenomena that often occur concurrently in the neuropathological state; neurotoxicity mediated by these multiple stresses contribute to the pathogenesis and progression of virtually all the neurodegenerative diseases. We aim to study how microglia are able to survive and verily outperform even in this scenario, while keeping the translational aspect in mind.
Research Highlights :
The research of our lab aims at studying how chronic inflammation, endoplasmic reticulum stress, and oxidative stress can affect brain function at the molecular level. These stresses are associated phenomena that often occur concurrently in the neuropathological state; neurotoxicity mediated by these multiple stresses contribute to the pathogenesis and progression of virtually all the neurodegenerative diseases. We aim to study how microglia are able to survive and verily outperform even in this scenario, while keeping the translational aspect in mind. In another line of research, we are interested in understanding how the bacterial components activate ER stress in eukaryotic cells and if the activations benefit the host organism or the bacteria. Also, we are investigating whether Caspase inhibitors identified by our group can be used to prevent lymphocyte apoptosis during Sepsis, a bacterial infectious disease. We use cell lines, primary cells and mouse models for our research.
Recent Publications :
1. Asveda T, Talwar P, Ravanan P*. (2023)
Exploring microglia and their phenomenal concatenation of stress responses in neurodegenerative disorders.
Life Sci. 2023 Sep 1;328:121920.
Link: doi: 10.1016/j.lfs.2023.121920.
Impact Factor: 6.7
2. Divya S, Ravanan P*. (2023)
Cellular battle against endoplasmic reticulum stress and its adverse effect on health.
Life Sciences. 2023 Apr 17;323:121705.
Link: doi: 10.1016/j.lfs.2023.121705.
Impact Factor: 6.7
3. Ravanan P*, Firoz A*, Saha P, Prashar T, Talwar P. (2023)
Genome-wide screening and identification of potential kinases involved in endoplasmic reticulum stress responses.
Life Sciences. 2023 Mar 15;317:121452.
Link: doi: 10.1016/j.lfs.2023.121452.
Impact Factor: 6.7
4. Talwar P*, Singh P, Ravanan P* (2023)
Structure-Based Virtual Screening and Discovery of New Bi-functional DAPK1 inhibitors.
Molecular Biotechnology.
Molecular Biotechnology. 2023 Jun 23.
Link: doi: 10.1007/s12033-023-00744-9.
Impact Factor: 2.9
5. Singla RK, De R, Efferth T, Mezzetti B, Uddin Md S, Sanusi, Ntie-Kang F,…Ravanan P,… Atanasov AG, Shen B, The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis. (2023)
Phytomedicine, Volume 108, Jan 2023, 154520.
Link: https://doi.org/10.1016/j.phymed.2022.154520
Impact Factor: 7.9
6. Narra Sai S, Sarah R, Rondeau P, Patche J, Veeren B, Gonthier MG, Viranaicken W, Diotel N, Ravanan P, d' Hellencourt CL, Meilhac O* (2022)
ApoA-I Nanoparticles as Curcumin Carriers for Cerebral Endothelial Cells: Improved Cytoprotective Effects against Methylglyoxal.
Pharmaceuticals (Basel), 2022 Mar 13: 15(3): 347.
Link: https://www.mdpi.com/1424-8247/15/3/347
Impact Factor: 5.2
7. Gopinath PM, Twayana KS, Ravanan P*, John Thomas, Mukherjee A, Jenkins DF, Chandrasekaran N*.
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes. (2021)
Particle and Fibre Toxicology, 2021 Sep 8;18(1):35.
Link: doi.org/10.1186/s12989-021-00428-9
Impact Factor: 10.0
8. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, ...Ravanan P….,et al.,
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy, 2021, 17 (1), 1-382. (2021)
https://doi.org/10.1080/15548627.2020.1797280.
Link: doi/full/10.1080/15548627.2020.1797280
Impact factor: 13.0
