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Research Highlights :
Dr. D. Siva Sundara Kumar’s area of research focuses on the following themes
- Neurodegenerative Pathophysiology: Investigating the underlying molecular mechanisms driving Alzheimer’s and Parkinson’s diseases.
- Molecular motors Tau and Autophagy: Elucidating the mechanistic interplay between Kinesin-1 molecular motor dysfunction, Tau aggregation, and autophagy impairment in Alzheimer’s disease.
- Neuroprotective Drug Discovery: Identification of novel neuroprotective leads through the screening of bioactive compounds from chemical libraries and natural sources.
- Fungal Pathogenesis: Characterization of sphingolipid metabolism as a therapeutic target to disrupt Candida biofilm formation and virulence.
- Antiviral Therapeutics: Screening small molecule libraries to identify potent inhibitors against SARS-CoV-2
Recent Publications :
- Selvarasu K, Singh AK, Dakshinamoorthy A, Sreenivasmurthy SG, Iyaswamy A, Radhakrishnan M, Patnaik S, Huang JD, Williams LL, Senapati S, Durairajan SSK*. Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation. Biomedicines. 2023 Dec 19;12(1):5. (I.F.: 4.7) https://doi:10.3390/biomedicines12010005
- Selvarasu K, Singh AK, Iyaswamy A, GopalkrishnashettySreenivasmurthy S, Krishnamoorthi S, Bera AK, Huang JD, Durairajan SSK*. Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models. Front Mol Biosci. 2022 Oct 25;9:1050768. https://pubmed.ncbi.nlm.nih.gov/36387285/ (I.F: 6.113),
- Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Reddi RN, Kammala AK, Vasudevan K, Senapati S, Zhu Z, Su CF, Liu J, Guan XJ, Chua KK, Cheung KH, Chen H, Zhang HJ, Zhang Y, Song JX, Durairajan SSK*, Li M*. Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy. Front Mol Biosci. 2022 9:1030534
- Iyaswamy A, Wang X, Krishnamoorthi S, Kaliamoorthy V, Sreenivasmurthy SG, Durairajan SSK, Song JX, Tong BC, Zhu Z, Su CF, Liu J, Cheung KH, Lu JH, Tan JQ, Li HW, Wong MS, Li M. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models. Redox Biol. 2022 May;51:102280.(IF: 10.787)
- Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BC, Cheung KH, Tan JQ, Lu JH, Durairajan SSK*, Song JX*, Li M*. Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. Phytomedicine. 2022 96, 153887. https://pubmed.ncbi.nlm.nih.gov/34936968/ (IF: 6.656)
- Durairajan SSK*, Selvarasu K, Bera MR, Rajaram K, Iyaswamy A, Li M. Alzheimer's Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration. Curr Mol Pharmacol. 2022;15(2):361-379. (I.F: 3.855)
- Liang LJ, Jeewon R, Dhandevi P, Durairajan SSK, Li H, Lin FC, Wang HK. A Novel Species of Penicillium With Inhibitory Effects Against Pyricularia oryzae and Fungal Pathogens Inducing Citrus Diseases. Front Cell Infect Microbiol. 2021 Feb 10;10:604504.
- Iyaswamy A, Krishnamoorthi SK, Liu YW, Song JX, Kammala AK, Sreenivasmurthy SG, Malampati S, Tong BCK, Selvarasu K, Cheung KH, Lu JH, Tan JQ, Huang CY, Durairajan SSK*, Li M*. Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease. Front Pharmacol. 2020; 11: 584770. (IF 2020: 4.2236).
- Iyaswamy A, Krishnamoorthi SK, Zhang H, Sreenivasmurthy SG, Zhu Z, Liu J, Su CF, Guan XJ, Wang ZY, Cheung KH, Song JX, Durairajan SSK*, Li M*. Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease. Phytomedicine. 2021 Oct;91:153648. (IF 2024:5.12)
- Iyaswamy A, Krishnamoorthi SK, Song JX, Yang CB, Zhang H, Kaliyamoorthy V, Sravan GS, Wang ZY, Zhu Z, Malampati S, Tong CT, Cheung KH, Lu JH, Durairajan SSK* Li M*. NeuroDefend, a novel traditional Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease. J Food Drug Anal. 2020; 28:132-146. (IF 2019: 4.727).
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