Dr. M. Shiva Prasad

Dr. M. Shiva Prasad

Name: Dr. M. Shiva Prasad
Designation: Assistant Professor
Phone: 8489022219
Email: shivaprasad@cutn.ac.in


Biographic Sketch:
Madavi Shiva Prasad (MSP) hails from Adilabad District, Telangana State, India. He received his B.Sc. in Biochemistry from Kakatiya University and MSc in Organic Chemistry from Osmania University, Hyderabad. He began his Doctoral studies in Organic Chemistry under the direction of Prof. D. B. Ramachary, School of Chemistry, University of Hyderabad, Hyderabad. During his time in Ph. D., the formation of secondary catalytic species, "Aminal" mechanism was firmly elucidated by him for the first time. His thesis title "High-Yielding Stereoselective Synthesis of Drug-like Molecules through Barbas-Michael and Metal-free Reductive Coupling Reactions". He joined the Central University of Tamil Nadu, Tiruvarur, India in 2013, Where he is currently an Assistant Professor of Chemistry (Senior scale). His research interests span around the asymmetric synthesis of small natural products, natural product mimics, and biologically potent scaffolds by exploiting catalysis. He has guided 1 Ph.D., 1 M. Phil, and 44 PG dissertations. To date, MSP completed 2 major research projects (PI-SERB -92 lakhs) and one Major research project is ongoing (Co-PI-DBT-70 Lakhs). He has qualified for GATE, NET, awarded CSIR - JRF, and CSIR - SRF. He has been serving as a member of various professional bodies, a Life member Chemical Research Society of India (CRSI), a Member of the American Chemical Society, a Member of the Royal Society of Chemistry (MRSC), and a Member of the Board of Studies.

Research Highlights :

MSP research group focuses on two major research areas:


Synthesis of chiral molecules primarily relies on catalysis. Organocatalysis mainly follows the iminium/enamine mechanism. MSP group focuses on developing synthetic methodologies via organocatalysis that could induce chirality in two primary modes.

1. Hydrogen –bond- directing catalysis
2. Steric Shielding Catalysis

MSP group research interests center around the asymmetric synthesis of small natural products and natural product-like molecules by exploiting catalysis. His research group also focuses on developing new synthetic methods to generate morphologically and functionally complex small chiral organic molecules with biological activity.


Recently MSP research group focussed on developing a robust and sustainable approach for constructing functionally rich optically pure heterocyclic frameworks via [4+2]-addition of in situ generated trienamine from a specially designed 2-(E)-benzylidine-3-pyrrolidinyl acraldehyde as a synthon.

MSP research group is also interested in other aminocatalytic cascade reactions by employing ketiminesas a potential synthon for constructing biologically potential spiroheterocycles.

Recent Publications :

1. Madavi S. Prasad,*Aman Kumar Jha and, Sankar Bharani, “Stereoselective Synthesis of Functionally Rich Spirooctahydroquinoline Oxindoles via Enynamide Cycloisomerisation-/[4+2]-Addition Sequence” Adv. Synth.Catal.,2024, xx, 202400162.  https://doi.org/10.1002/adsc.202400162

2. Madavi S. Prasad,*M. Ramesh, Aman Kumar Jha, Sankar Bharani, Souvik Saha, ThoudamBedanta, Ponnada Chandrasekhar,and M. Sarasija, “Amine Catalyzed Remote [4+2] Annulation of Indole Tethered Enal and Oxindole Olefin to Access Optically Pure HydrocarbazoleSpirooxindoleScaffolds Asian J. Org. Chem. 2024, xx, e202400061. https://doi.org/10.1002/ajoc.202400061

3.Madavi S. Prasad,* Sankar Bharani, Aman Kumar Jha, Sugali Chetan Naik, Murugesan Sivaprakash, and L. Raju Chowhan, “Enantioselective synthesis of octahydrofuranoindole core of aspidosperma alkaloids via Diels Alder/reduction/fluoroetherification reaction sequence” Chem. Asian J.,2023, 18, e202300419.https://doi.org/10.1002/asia.202300419

4. Madavi S. Prasad,* Sankar Bharani, Murugesan Sivaprakash, Prabha Vadivelu, D. Siva Sundara Kumar and L. Raju Chowhan, “N-2,2,2-trifluoroethylisatinketimine as an unprecedented 1,2-dipolarophile for [3+2] addition to access optically pure spiro- thiazolidine oxindoles” Org. Biomol. Chem.,2023, 21, 4972-4976. https://doi.org/10.1039/D3OB00685A

5. Biplob Borah, Murugesan Sivaprakash, Samrita Sharma, Madavi S. Prasad*, and, L. Raju Chowhan, “Blossoming of polyenamine catalysis in asymmetric synthesis: Scope and future applications” Chem. Asian J.,2023, 18, e202300370.  https://doi.org/10.1002/asia.202300370

6. Madavi S. Prasad*, Murugesan Sivaprakash, and Sankar Bharani, Trienamine catalyzed unprecedented remote olefin E/Z isomerization/[4+2]-cycloaddition reaction to access spirooxindole hexahydroindoles. Org. Biomol. Chem.,2023, 21, 945 – 949. https://doi.org/10.1039/D2OB02228A

7. Madavi S. Prasad*, and Murugesan Sivaprakash, Asymmetric synthesis of the perhydroepoxyethanoindole core via sequential [4 + 2]-addition/ reduction/fluoroannulation reactions. Org. Biomol. Chem., 2023, 21, 339-344. https://doi.org/10.1039/D2OB02058K

8. Biplob Borah, Murugesan Sivaprakash, Madavi S. Prasad*, and L. Raju Chowhan, Visible-light-induced Organophotocatalytic and Singlet Oxygen-initiated Domino construction of 1,4-dihydropyridines, quaternary centered C-3 functionalized Spiro[indoline-3,4'-pyridines] and C-11 functionalized Spiro[indeno-[1,2b]quinoxalines-11,4'-pyridines]. Org. Biomol. Chem., 2023, 21, 1518-1530. https://doi.org/10.1039/D3OB00043E

9. Biplob Borah, ..., Madavi S. Prasad*, and L. Raju Chowhan*, Stereoselective synthesis of CF3-containing spirocyclic-oxindoles using N-2,2,2-trifluoroethylisatin ketimines: An update RSC Adv.,2023, 13, 7063-7075.https://doi.org/10.1039/D3RA00017F

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