Dr. Nagarajan Raju

Dr. Nagarajan Raju

Name: Dr. Nagarajan Raju
Designation: Assistant Professor
Phone: 04366-277261
Email: nagarajanr@cutn.ac.in

 

Biographic Sketch:
Dr. Nagarajan R is an Assistant Professor in the Department of Epidemiology and Public Health. He completed his Bachelor’s and Master’s degrees in Bioinformatics at Bharathidasan University. Subsequently, he worked as a Project Assistant at the Bioinformatics Centre, IISc Bengaluru where he focused on biological data analysis. He pursued his PhD in the department of Biotechnology at IIT Madras under the guidance of Dr. M. Michael Gromiha. During his doctoral research, he focused on the analysis of protein–nucleic acid interactions and their binding patterns. In 2016, he began his postdoctoral research at Vanderbilt University Medical Center, USA, where he worked on the analysis of antibody repertoires of infected and vaccinated individuals, and contributed to algorithm and web-application development. He later moved to Emory University, USA, as an Associate Scientist in Bioinformatics, where his research expanded to genome-wide and single-cell RNA sequencing analyses. Dr. Nagarajan is the recipient of several prestigious honors, including the AU–CBT Excellence Award from BRSI, Research Award from IIT Madras, DBT Incentive Award, Publons Top Peer Reviewer Award, Springer Nature Editor of Distinction Award, and six international travel awards. He has handled over 140 manuscripts as an editor and reviewed ~130 manuscripts for high-impact journals.
   
Research Highlights :

Our research primarily focuses on the development of bioinformatics tools, novel algorithms, and databases across diverse areas, including macromolecular structural analysis, humoral immune response analysis, single-cell RNA sequencing (scRNA-seq) analysis, regulatory response element analysis, and related domains.



Recent Publications :

  1. Nagarajan R*, Kramer K*, Cavallaro M, Diotti RA, Shiakolas AR, Mota YC et al. (2024) Multiplexed antibody sequencing and profiling of the human HA-specific memory B cell response following influenza vaccination, Journal of Immunology, 213(11), 1605-1619(*Equal first author)
  2. Peter D. Kwong, Hua Wang Cheng, James L. Dal Santo, Chen-Hsiang Shen, Tatsiana Bylund, ……….. Amarendra Pegu; Nagarajan R; Reda Rawi et al. (2024) Potent cross-reactive HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques, Cell ,187(25), 7214-7231
  3. Alexandra A. Abu-Shmais, Rose J. Miller, Alexis K. Janke, Rachael M. Wolters, Clinton M. Holt, Nagarajan R, Robert H. Carnahan, James E. Crowe Jr, Jarrod J. Mousa and Ivelin S. Georgiev (2024) Potent HPIV3-neutralizing IGHV5-51 antibodies identified from multiple individuals show light chain and CDRH3 promiscuity, Journal of Immunology,212(9), 1450-1456.
  4. Qiankun Wang, Kolin M. Clark, Ritudwhaj Tiwari, Nagarajan R, Gregory K Tharp, Jeffrey Rogers, R. Alan Harris, Muthuswamy Raveendran, Steven E. Bosinger, Tricia H Burdo, Guido Silvestri and Liang Shan (2024) The CARD8 Inflammasome Dictates HIV/SIV Pathogenesis and Disease Progression, Cell, 187(5), 1223-1237
  5. Schommers P, Dae Sung Kim, Schlotz M, Kreer C, Eggeling R, Hake A, Stecher M, Park J, Meryem S. Ercanoglu, Henning Gruell, Gieselmann L, Elvin Ahmadov, Rene Y. Lawong, Eva Heger, Elena Knops, Christoph Wyen, Tim Kümmerle, Katja Römer, Stefan Scholten, Timo Wolf, Christoph Stephan, Isabelle Suárez, Nagarajan R, Adhikari A, et al. (2023) Dynamics and durability of HIV-1 neutralization are determined by viral replication, Nature Medicine, 29, 2763–2774
  6. Pilewski K, Wall S, Richardson S, Clark K, Hermanus T, Binshtin E, Venkat R, Sautto G, Kramer K, Shiakolas A, Setliff I, Salas J, Mapengo R, Suryadevara N, Brannon J, Beebout C, Parks R, Nagarajan R et al. (2023) Functional HIV-1/HCV cross-reactive antibodies isolated from a chronically co-infected donor, Cell Reports, 42(2), 112044
  7. Nagarajan R*, Xiaoyan Zhan*, Subash Das, LovkeshKarwal, Hansi J. Dean,   James E. Crowe Jr., Robert H. Carnahan and Georgiev IS (2022) Neutralization Fingerprinting Technology for Characterizing Polyclonal Antibody Responses to Dengue Vaccines, Cell Reports, 41(11), 111807.
  8. Amyn AM*, Nagarajan R* et al. (2022) Sequence and functional properties of a public HIV-specific antibody clonotype, iScience, 25 (1), 103564
  9. Kramer K, Wilfong EM, Voss K, Barone SM, Roe CE, Shiakolas AR, Nagarajan R et al. (2022) Single Cell Profiling Reveals BNT162b2 SARS-CoV-2 RNA Vaccine Antigen-Specific Lymphocyte Subsets, Nature Communications,13, 3466.
  10. Shiakolas AR, Johnson N, Kramer KJ, Suryadevara N, Wrapp D, Periasamy S, Pilewski KA, Nagarajan R et al. (2022) Efficient discovery of potently neutralizing SARS-CoV-2 antibodies using LIBRA-seq with ligand blocking, Nature Biotechnology, 40, 1270–1275

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